My observations using Ivomec are that around the 3rd day I experienced a substantial breakout of surface-based whiteheads across both cheeks and lesser so on my neck, decolletage and across my upper back. It should be noted that I was not applying the Ivomec onto my upper back. Within 2 days, the whiteheads are clearing with only the occasional one appearing. In the last 7 days there have not been any of the painful, deeper cystic-type swellings.
Each time I have applied the Ivomec, I have noticed a slight warming sensation of the skin. The feeling dissipates within seconds. There is no accompanying flushing of the skin, it's is only a sensation. I don't know if the sensation is due to the ivermectin itself but I suspect it is more likely to be from one of the carrier ingredients (glycerol formal or propylene glycol) and I'll bet it is specifically the propylene glycol which is used in personal lubricant products because of the warming sensation it provides.
Regarding the safety of using Ivomec to treat my rosacea, I have found the following information:
Ivermectin works by disrupting nerve impulses in parasites. It binds to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells which leads to an increase in the permeability of the cell membrane, thereby paralyzing and killing the invaders.
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macro-cyclic lactones have a low affinity for other mammalian ligandgated chloride channels and they do not readily cross the blood-brain barrier.
Source: http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=27632
It's exactly one month until my appointment with my dermatologist.
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